Risk of upper gastrointestinal bleeding from different drug combinations.
Identifieur interne : 000260 ( Main/Exploration ); précédent : 000259; suivant : 000261Risk of upper gastrointestinal bleeding from different drug combinations.
Auteurs : Gwen M C. Masclee [Pays-Bas] ; Vera E. Valkhoff [Pays-Bas] ; Preciosa M. Coloma [Pays-Bas] ; Maria De Ridder [Pays-Bas] ; Silvana Romio [Pays-Bas] ; Martijn J. Schuemie [Pays-Bas] ; Ron Herings [Pays-Bas] ; Rosa Gini [Italie] ; Giampiero Mazzaglia [Italie] ; Gino Picelli [Italie] ; Lorenza Scotti [Italie] ; Lars Pedersen [Danemark] ; Ernst J. Kuipers [Pays-Bas] ; Johan Van Der Lei [Pays-Bas] ; Miriam C J M. Sturkenboom [Pays-Bas]Source :
- Gastroenterology [ 1528-0012 ] ; 2014.
Descripteurs français
- KwdFr :
- Acide acétylsalicylique (administration et posologie), Acide acétylsalicylique (effets indésirables), Antagonistes des récepteurs des minéralocorticoïdes (effets indésirables), Anti-inflammatoires non stéroïdiens (administration et posologie), Anti-inflammatoires non stéroïdiens (effets indésirables), Anticoagulants (effets indésirables), Europe, Facteurs de risque, Hormones corticosurrénaliennes (effets indésirables), Humains, Hémorragie gastro-intestinale (), Inhibiteurs des cyclooxygénases (administration et posologie), Inhibiteurs des cyclooxygénases (effets indésirables), Interactions médicamenteuses, Relation dose-effet des médicaments, Évaluation des risques.
- MESH :
- administration et posologie : Acide acétylsalicylique, Anti-inflammatoires non stéroïdiens, Inhibiteurs des cyclooxygénases.
- effets indésirables : Acide acétylsalicylique, Antagonistes des récepteurs des minéralocorticoïdes, Anti-inflammatoires non stéroïdiens, Anticoagulants, Hormones corticosurrénaliennes, Inhibiteurs des cyclooxygénases.
- Europe, Facteurs de risque, Humains, Hémorragie gastro-intestinale, Interactions médicamenteuses, Relation dose-effet des médicaments, Évaluation des risques.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (adverse effects), Anti-Inflammatory Agents, Non-Steroidal (administration & dosage), Anti-Inflammatory Agents, Non-Steroidal (adverse effects), Anticoagulants (adverse effects), Aspirin (administration & dosage), Aspirin (adverse effects), Cyclooxygenase Inhibitors (administration & dosage), Cyclooxygenase Inhibitors (adverse effects), Dose-Response Relationship, Drug, Drug Interactions, Europe, Gastrointestinal Hemorrhage (chemically induced), Humans, Mineralocorticoid Receptor Antagonists (adverse effects), Risk Assessment, Risk Factors.
- MESH :
- chemical , administration & dosage : Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Cyclooxygenase Inhibitors.
- chemical , adverse effects : Adrenal Cortex Hormones, Anti-Inflammatory Agents, Non-Steroidal, Anticoagulants, Aspirin, Cyclooxygenase Inhibitors, Mineralocorticoid Receptor Antagonists.
- geographic : Europe.
- chemically induced : Gastrointestinal Hemorrhage.
- Dose-Response Relationship, Drug, Drug Interactions, Humans, Risk Assessment, Risk Factors.
Abstract
Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhibitors (COX-2 inhibitors), and low-dose aspirin with other drugs.
DOI: 10.1053/j.gastro.2014.06.007
PubMed: 24937265
Affiliations:
- Danemark, Italie, Pays-Bas
- Hollande-Méridionale, Lombardie, Utrecht (province)
- Milan, Rotterdam, Utrecht
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Le document en format XML
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Masclee</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: g.masclee@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Valkhoff, Vera E" sort="Valkhoff, Vera E" uniqKey="Valkhoff V" first="Vera E" last="Valkhoff">Vera E. Valkhoff</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Coloma, Preciosa M" sort="Coloma, Preciosa M" uniqKey="Coloma P" first="Preciosa M" last="Coloma">Preciosa M. Coloma</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Ridder, Maria" sort="De Ridder, Maria" uniqKey="De Ridder M" first="Maria" last="De Ridder">Maria De Ridder</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Biostatistics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Romio, Silvana" sort="Romio, Silvana" uniqKey="Romio S" first="Silvana" last="Romio">Silvana Romio</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schuemie, Martijn J" sort="Schuemie, Martijn J" uniqKey="Schuemie M" first="Martijn J" last="Schuemie">Martijn J. Schuemie</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Herings, Ron" sort="Herings, Ron" uniqKey="Herings R" first="Ron" last="Herings">Ron Herings</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; PHARMO Institute, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; PHARMO Institute, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Gini, Rosa" sort="Gini, Rosa" uniqKey="Gini R" first="Rosa" last="Gini">Rosa Gini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Agenzi Regionali di Sanità della Toscana, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Agenzi Regionali di Sanità della Toscana, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Mazzaglia, Giampiero" sort="Mazzaglia, Giampiero" uniqKey="Mazzaglia G" first="Giampiero" last="Mazzaglia">Giampiero Mazzaglia</name><affiliation wicri:level="1"><nlm:affiliation>Health Search, Italian College of General Practitioners, Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Health Search, Italian College of General Practitioners, Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Picelli, Gino" sort="Picelli, Gino" uniqKey="Picelli G" first="Gino" last="Picelli">Gino Picelli</name><affiliation wicri:level="1"><nlm:affiliation>Pedianet, Societá Servizi Telematici SRL, Padova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Pedianet, Societá Servizi Telematici SRL, Padova</wicri:regionArea><wicri:noRegion>Padova</wicri:noRegion></affiliation></author><author><name sortKey="Scotti, Lorenza" sort="Scotti, Lorenza" uniqKey="Scotti L" first="Lorenza" last="Scotti">Lorenza Scotti</name><affiliation wicri:level="3"><nlm:affiliation>Università degli Studi di Milano-Bicocca, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Università degli Studi di Milano-Bicocca, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Pedersen, Lars" sort="Pedersen, Lars" uniqKey="Pedersen L" first="Lars" last="Pedersen">Lars Pedersen</name><affiliation wicri:level="1"><nlm:affiliation>Clinical Epidemiology, Aarhus University Hospital, Århus Sygehus, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Clinical Epidemiology, Aarhus University Hospital, Århus Sygehus, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kuipers, Ernst J" sort="Kuipers, Ernst J" uniqKey="Kuipers E" first="Ernst J" last="Kuipers">Ernst J. Kuipers</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Der Lei, Johan" sort="Van Der Lei, Johan" uniqKey="Van Der Lei J" first="Johan" last="Van Der Lei">Johan Van Der Lei</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C J M" last="Sturkenboom">Miriam C J M. Sturkenboom</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Gastroenterology</title><idno type="eISSN">1528-0012</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (adverse effects)</term><term>Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)</term><term>Anti-Inflammatory Agents, Non-Steroidal (adverse effects)</term><term>Anticoagulants (adverse effects)</term><term>Aspirin (administration & dosage)</term><term>Aspirin (adverse effects)</term><term>Cyclooxygenase Inhibitors (administration & dosage)</term><term>Cyclooxygenase Inhibitors (adverse effects)</term><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Europe</term><term>Gastrointestinal Hemorrhage (chemically induced)</term><term>Humans</term><term>Mineralocorticoid Receptor Antagonists (adverse effects)</term><term>Risk Assessment</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide acétylsalicylique (administration et posologie)</term><term>Acide acétylsalicylique (effets indésirables)</term><term>Antagonistes des récepteurs des minéralocorticoïdes (effets indésirables)</term><term>Anti-inflammatoires non stéroïdiens (administration et posologie)</term><term>Anti-inflammatoires non stéroïdiens (effets indésirables)</term><term>Anticoagulants (effets indésirables)</term><term>Europe</term><term>Facteurs de risque</term><term>Hormones corticosurrénaliennes (effets indésirables)</term><term>Humains</term><term>Hémorragie gastro-intestinale ()</term><term>Inhibiteurs des cyclooxygénases (administration et posologie)</term><term>Inhibiteurs des cyclooxygénases (effets indésirables)</term><term>Interactions médicamenteuses</term><term>Relation dose-effet des médicaments</term><term>Évaluation des risques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Aspirin</term><term>Cyclooxygenase Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Anti-Inflammatory Agents, Non-Steroidal</term><term>Anticoagulants</term><term>Aspirin</term><term>Cyclooxygenase Inhibitors</term><term>Mineralocorticoid Receptor Antagonists</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Acide acétylsalicylique</term><term>Anti-inflammatoires non stéroïdiens</term><term>Inhibiteurs des cyclooxygénases</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Gastrointestinal Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Acide acétylsalicylique</term><term>Antagonistes des récepteurs des minéralocorticoïdes</term><term>Anti-inflammatoires non stéroïdiens</term><term>Anticoagulants</term><term>Hormones corticosurrénaliennes</term><term>Inhibiteurs des cyclooxygénases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term><term>Drug Interactions</term><term>Humans</term><term>Risk Assessment</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Europe</term><term>Facteurs de risque</term><term>Humains</term><term>Hémorragie gastro-intestinale</term><term>Interactions médicamenteuses</term><term>Relation dose-effet des médicaments</term><term>Évaluation des risques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inhibitors (COX-2 inhibitors), and low-dose aspirin with other drugs.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Italie</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Lombardie</li><li>Utrecht (province)</li></region><settlement><li>Milan</li><li>Rotterdam</li><li>Utrecht</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Masclee, Gwen M C" sort="Masclee, Gwen M C" uniqKey="Masclee G" first="Gwen M C" last="Masclee">Gwen M C. Masclee</name></region><name sortKey="Coloma, Preciosa M" sort="Coloma, Preciosa M" uniqKey="Coloma P" first="Preciosa M" last="Coloma">Preciosa M. Coloma</name><name sortKey="De Ridder, Maria" sort="De Ridder, Maria" uniqKey="De Ridder M" first="Maria" last="De Ridder">Maria De Ridder</name><name sortKey="Herings, Ron" sort="Herings, Ron" uniqKey="Herings R" first="Ron" last="Herings">Ron Herings</name><name sortKey="Kuipers, Ernst J" sort="Kuipers, Ernst J" uniqKey="Kuipers E" first="Ernst J" last="Kuipers">Ernst J. Kuipers</name><name sortKey="Romio, Silvana" sort="Romio, Silvana" uniqKey="Romio S" first="Silvana" last="Romio">Silvana Romio</name><name sortKey="Schuemie, Martijn J" sort="Schuemie, Martijn J" uniqKey="Schuemie M" first="Martijn J" last="Schuemie">Martijn J. Schuemie</name><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C J M" last="Sturkenboom">Miriam C J M. Sturkenboom</name><name sortKey="Valkhoff, Vera E" sort="Valkhoff, Vera E" uniqKey="Valkhoff V" first="Vera E" last="Valkhoff">Vera E. Valkhoff</name><name sortKey="Van Der Lei, Johan" sort="Van Der Lei, Johan" uniqKey="Van Der Lei J" first="Johan" last="Van Der Lei">Johan Van Der Lei</name></country><country name="Italie"><noRegion><name sortKey="Gini, Rosa" sort="Gini, Rosa" uniqKey="Gini R" first="Rosa" last="Gini">Rosa Gini</name></noRegion><name sortKey="Mazzaglia, Giampiero" sort="Mazzaglia, Giampiero" uniqKey="Mazzaglia G" first="Giampiero" last="Mazzaglia">Giampiero Mazzaglia</name><name sortKey="Picelli, Gino" sort="Picelli, Gino" uniqKey="Picelli G" first="Gino" last="Picelli">Gino Picelli</name><name sortKey="Scotti, Lorenza" sort="Scotti, Lorenza" uniqKey="Scotti L" first="Lorenza" last="Scotti">Lorenza Scotti</name></country><country name="Danemark"><noRegion><name sortKey="Pedersen, Lars" sort="Pedersen, Lars" uniqKey="Pedersen L" first="Lars" last="Pedersen">Lars Pedersen</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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